个人简介

宋凤瑞，曾担任中国科学院长春应用化学研究所研究员，现为广东粤港澳大湾区黄埔材料研究院核心科学家。博士生导师，长春市优秀人才，中国质谱学会常务理事，药物质量分析与过程控制分会常务理事，中国医药生物技术协会药物分析分会委员。《药学学报》、《质谱学报》等期刊编委。作为项目负责人完成及正在承担的国家自然科学基金项目6项，省部级科研项目及横向课题30余项；参与973计划及重大新药创制等项目多项。获得吉林省科技进步一等奖4项，二等奖3项，三等奖2项；中国中西医结合学会科学技术二等奖1项，吉林省自然科学学术成果二等奖1项。近年来发表论文300余篇，参编《中药质谱分析》等专著2部。授权发明专利50余项。
宋凤瑞教授及其团队自九十年代起相继开展人参成分分析、人参加工工艺优化、人参压热过程中成分转化及互作机制研究等相关工作，建立了人参皂苷及其寡糖的快速质谱表征方法，开发了人参加热、压热、pH调控及密闭压热加工工艺，阐明了人参高温处理过程中的人参皂苷转化规律为中、高分子量人参皂苷含量降低，生成了鲜参中含量稀少的小分子量人参皂苷，并阐明了C-20糖基水解生成次级皂苷的反应机理。发现了热加工过程中鲜参中的麦芽糖和氨基酸发生了美拉德反应，生成了新的氨基酸衍生物。与吉林省人参科学研究院合作，完成了吉林省重大科技攻关项目—《吉林省人参药材、饮片及配伍组方物质基础和质量控制中标准化关键技术研究》

相关专利：
(1)徐家林，宋凤瑞，卢智慧，吴学明，李安章，王安宁. 陶瓷膜微滤组件、人参提取液微滤装置。202321964944.1,授权日期：2023/07/24
(2)郑重, 宋凤瑞, 刘舒, 刘志强, 李川.一种人参皂苷饮品的制备方法，ZL201510881658.2, 授权日期：2018/05/15
(3)宋凤瑞, 苏玲, 陈维佳, 皮子凤, 邢俊鹏, 刘志强. 一种参芪芝药性菌质液体发酵方法. ZL 201410088715.7, 授权日期：2016/05/11
(4)宋凤瑞，张乐，王琦，刘志强，刘淑莹.一种醋制人参的加工方法. ZL200910217950,
(5)宋凤瑞，张语迟，王淑敏，刘志强，刘淑莹.一种增加人参总皂苷提取物中稀有皂苷含量的方法. ZL200810050535.4，授权日期：2011/05/25
(6)宋凤瑞,张语迟,刘志强,王淑敏,刘淑莹.一种人参保健品冲剂的制备方法.发明专利, ZL 200810051162.2，授权日期：2011-8-3
(7)刘淑莹，杜芹芹，邢俊鹏，宋凤瑞，刘志强。一种增加红参中总皂苷、小极性皂苷和精氨酸双糖苷含量的炮制方法
(8)刘淑莹，张旭，刘志强，宋凤瑞，张宪臣。一种从人参根中获得二醇型人参皂苷F2含量较高的人参皂苷粗提物的方法。
(9)赵向国, 宋凤瑞, 王淑敏, 刘志强. 一种采用酸催化增加黄芪总提取物中黄芪甲苷含量的方法. ZL201110375402.6, 授权日期：2015/01/14
(10)宋凤瑞, 齐静静, 邢俊鹏, 刘志强, 刘淑莹.一种中药龙胆的质量检测方法.申请号. ZL200910066875.0，授权日期：2013/01/02

相关获奖
(1)2022年吉林省科技进步一等奖—《一类中药参一胶囊产业化新突破及抗肿瘤机制临床新应用研究，宋凤瑞（第5完成人,5/15）
(2)2012年吉林省科技进步一等奖—《中药活性筛选、结构表征及质量控制的应用基础研究》,宋凤瑞（第2完成人,2/15）
(3)2009年吉林省科技进步一等奖—《人参、西洋参标准化及系列产品开发研究》,宋凤瑞（第六完成人，6/15）
(4)2006年吉林省科技进步一等奖——《基于质谱学技术的中药复杂体系的分析方法学及物质基础研究,宋凤瑞（第3完成人，3/15）
(5)2002年吉林省科技进步二等奖《人参四逆汤药效活性成分及其作用机理研究和软电离质谱的研究》，宋凤瑞（第11完成人，11/21）

代表性文章：
(1)李薇，宋凤瑞，李安章，吴学明，侯森，刘舒，后宗.人参有效成分闪式快速提取工艺优化及抗氧化活性研究 .特产研究，2024,961-967. DOI：10.16720/j.cnki.tcyj.2024.033
(2)Xin Meng，Hou Zong，Zhong Zheng，Junpeng Xing， Zhiqiang Liu，Fengrui Song*，Shu Liu*. Ligand‑targeted fishing of α‑glucosidase inhibitors from Tribulus terrestris L. based on chitosan‑functionalized multi‑walled carbon nanotubes with immobilized α‑glucosidase. Analytical and Bioanalytical Chemistry, 2023, 415: 2677–2692
(3)Wang AM, Fan YT, Fu J, Song FR*, Liu ZQ, Liu S*. Isoniazid Derivatization Strategy of Carboxyl-containing metabolites for LC-MS/MS Based Targeted Metabolomics. Analytical and Bioanalytical Chemistry, 2023, 415: 6345–6353.
(4)Fu J, Li J, Sun Y,  Liu S, Song F, Liu Z. In-depth investigation of the mechanisms of Schisandra chinensis polysaccharide mitigating Alzheimer’s disease rat via gut microbiota and feces metabolomics, International Journal of Biological Macromolecules2023, 232: 123488
(5)Aimin Wang， Minjie Shi， Junpeng Xing， Shu Liu*， Zhiqiang  Liu， Fengrui Song*. Treatment effects of Radix ginseng-Schisandra chinensis herb pair on Alzheimer’s disease: An investigation of MS-based metabolomics investigation. Journal of Pharmaceutical and Biomedical Analysis, 2022, 220,115007
(6)Xin Meng, Junpeng Xing , Shu Liu* , Zhiqiang Liu, Fengrui Song*,Comprehensive chemical profiling and potential chemical marker’s evaluation of Tribulus terrestris by UPLC-QTOF-MS in combination with ion mobility spectrometry. Journal of Pharmaceutical and Biomedical Analysis，2022,217:114839
(7)Aimin Wang，Zifeng Pi， Shu Liu*，Zhong  Zheng, Zhiqiang Liu， Fengrui Song*. Mass spectrometry -based urinary metabolomics for exploring the treatment effects of Radix ginseng-Schisandra chinensis herb pair on Alzheimer's disease in rats. Journal of Separation Science, 2022,44(16):3158-3166
(8)Xinyu Bian, Xiaoyu Zhuang, Zhong Zheng, Shu Liu*，Zhiqiang  Liu，Fengrui Song*. Unfolding and aggregation of oxidized metal-deficient superoxide dismutase and isoflavone inhibition based on ion mobility mass spectrometry and ThT fluorescence assay.Archives of Biochemistry and Biophysics, 2022,727,109306
(9)Naiyun Cui, Shu Liu*, Zhong Zheng, Zifeng Pi, Zhiqiang Liu, Fengrui Song*.The chemical profile of Fubai Chrysanthemum (Fubaiju) and its mechanism in preventing cataract based on ultrahigh‐performance liquid chromatography coupled with mass spectrometry and network pharmacology. Journal of Separation Science, 2022,45(13):2066
(10)Li Zong, Guorong Cheng, Jingwu Zhao, Xiaoyu Zhuang, Zhiqiang  Liu*，Fengrui Song*. Inhibitory Effect of Ursolic Acid on the Migration and Invasion of Doxorubicin-Resistant Breast Cancer.Molecules, 2021,27(4):1282
(11)Guorong Cheng，Zifeng Pi，Xiaoyu Zhuang， Zhong Zheng，Shu Liu*，Zhiqiang Liu，Fengrui Song*. The effects and mechanisms of aloe-emodin on reversing adriamycin-induced resistance of MCF-7/ADR cells. Phytotherapy Research, 2021;35:3886–3897
(12)Aimin Wang, Zifeng Pi,Su Liu, Zhong Zheng, Zhiqiang Liu, Fengrui Song. Mass spectrometry-based urinary metabolomics for exploring the treatment effects of Radix ginseng-Schisandra chinensis herb pair on Alzheimer's disease in rats. Journal of Separation Science, 2021, 44(16):3158-3166
(13)Fu J, Zhang H, Liu S, Wu J, Zhang Y, Gao Y, Song F, Qin Y, Hu X, Liu Z. An integrated strategy using LC-MS/MS combined with in vivo microdialysis for the simultaneous determination of lignans of Schisandra chinensis (Turcz.) Baill. Fructus and endogenous neurotransmitters: application in pharmacokinetic and pharmacodynamic studies [J]. Food Funct, 2021, 12(19): 8932-45.
(14)Guorong Cheng, Zifeng Pi, Zhong Zheng, Shu Liu*, Zhiqiang Liu, Fengrui Song*. Magnetic nanoparticles-based lactate dehydrogenase microreactor as a drug discovery tool for rapid screening inhibitors from natural products. Talanta, 2020,209:120544-6021
(15)Yufei Sun, Guifang Feng, Yan Zheng, Shu Liu, Yan Zhang, Zifeng Pi, Fengrui Song, Zhiqiang Liu.Putative Multiple Reaction Monitoring Strategy for The Comparative Pharmacokinetics of Postoral Administration Renshen-Yuanzhi Compatibility Through Liquid Chromatography-Tandem Mass Spectrometry. Journal of Ginseng Research, 2020, 44(1): 105-114
(16)Guorong Cheng. Junpeng Xing. Zifeng Pi. Shu Liu*. Zhiqiang Liu. Fengrui Song*. alpha-Glucosidase immobilization on functionalized Fe3O4 magnetic nanoparticles for screening of enzyme inhibitors. Chinese Chemical Letters. 2019, 30(3): 656-659
(17)Xiaoyu Zhuang, Xiuxiu Li, Bing Zhao, Zhiqiang Liu, Fengrui Song*, Jianzhong Lu*. Native Mass Spectrometry Based Method for Studying the Interactions between Superoxide Dismutase 1 and Stilbenoids. ACS Chemical Neuroscience,2020,11(2):184-190.
(18)Ningning Zhao, Shu Liu, Junpeng Xing, Zifeng Pi, Fengrui Song, Zhiqiang Liu. Trace determination and characterization of ginsenosides in rat plasma through magnetic dispersive solid-phase extraction based on core-shell polydopamine -coated magnetic nanoparticles. Journal of Pharmaceutical Analysis,2020, 10: 86e95.
(19)Guifang Feng,Yufei Sun, Shu Liu, Fengrui Song, Zifeng Pi, Zhiqiang Liu. Stepwise targeted matching strategy from in vitro to in vivo based on ultra-high performance liquid chromatography tandem mass spectrometry technology to quickly identify and screen pharmacodynamics constituents. Talanta. 2019, 194: 619-626
(20)Xinyu Bian. Bing Zhao. Bo Pang. Zhong Zheng. Shu Liu*. Zhiqiang Liu. Fengrui Song*.Separation, Quantification and Structural Study of (+)-Catechin and (-)-Epicatechin by Ion Mobility Mass Spectrometry Combined with Theoretical Algorithms. Chinese Journal of Chemistry, 2019, 37(6): 581-587.
(21)Guifang Feng, Zhiqiang Liu*, Shu Liu*, Junpeng Xing, Fengrui Song, Zifeng Pi. A target integration strategy for analyzing multidimensional chemical and metabolic substance groups of Ding-Zhi-Xiao-Wan prescription by using ultra-high performance liquid chromatography tandem mass spectrometry. J Chromatogr A. 2019, 1008.
(22)Yuan Zhou, Lihui Men, Zifeng Pi, Mengying Wei, Fengrui Song*, Chunfang Zhao*, Zhiqiang Liu. Fecal Metabolomics of Type 2 Diabetic Rats and Treatment with Gardenia jasminoides Ellis Based on Mass Spectrometry Technique. J. Agric. Food Chem. 2018, 66, 1591−1599
(23)Xueju Zhang, Zifeng Pi*, Zhong Zheng, Zhiqiang Liu, Fengrui Song*, Comprehensive investigation of in-vivo ingredients and action mechanism of iridoid extract from Gardeniae Fructus by liquid chromatography combined with mass spectrometry, microdialysis sampling and network pharmacology. J. Chromatogr. B 2018,1076: 70–76
(24)Li Zong, Junpeng Xing, Shu Liu*,  Zhiqiang Liu, Fengrui Song*. Cell metabolomics reveals the neurotoxicity mechanism of cadmium in PC12 Cells. Ecotoxicology and Environmental Safety 2018, 147: 26–33
(25)Bing Zhao, Xiaoyu Zhuang, Zifeng Pi, Shu Liu*, Zhiqiang Liu, Fengrui Song*. Determining the Effect of Catechins on SOD1 Conformation and Aggregation by Ion Mobility Mass Spectrometry Combined with Optical Spectroscopy. J. Am. Soc. Mass Spectrom. 2018, 29: 734Y741
(26)ZHANG Xue-Ju, LIU Shu , XING Jun-Peng , LIU Zhi-Qiang*, SONG Feng-Rui*. Effect of type 2 diatebes mellitus on flavonoid pharmacokinetics and tissue distribution after oral administration of Radix Scu-tellaria extract to rats. Chin J. Nat. Med. 2018, 16(6): 0418 0427
(27)Xueju Zhang, Lu Wang, Zhong Zheng, Zifeng Pi*, Zhiqiang Liu, Fengrui Song*. Online microdialysis-ultra performance liquid chromatography–massspectrometry method for comparative pharmacokinetic investigationon iridoids from Gardenia jasminoides Ellis in rats with differentprogressions of type 2 diabetic complications. J. Pharm. Biomed. Anal., 2017, 140:146-154
(28)Xiaoyu Zhuang, Bing Zhao, Shu Liu, Fengrui Song, Fengchao Cui, Zhiqiang Liu, Yunqi Li.Noncovalent interactions between superoxide dismutase and flavonoids studied by native mass spectrometry combined with molecular simulations. Analytical Chemistry, 2016, 88(23):11720-11726
(29)Ruixing Zhang, Xiaoyu Zhuang, Li Zong, Shu Liu, Zifeng Pi, Zhiqiang Liu, Fengrui Song*. Investigations on the cell metabolomics basis of multidrug resistance from tumor cells by ultra-performance liquid chromatography–mass spectrometry. Anal Bioanal Chem. 2016,408:5843–5854
(30)Lu Wang, Shu Liu, Xueju Zhang, Junpeng Xing, Zhiqiang Liu, Fengrui Song*, A strategy for identification and structural characterization of compounds from Gardenia jasminoides by integrating macro porous resin column chromatography and liquid chromatography-tandem mass spectrometry combined with ion-mobility spectrometry. J. Chromatogr. A. 2016 (1452): 47-57.
(31)Yan Zhang, Zifeng Pi, Fengrui Song, Zhiqiang Liu. Ginsenosides attenuate D-galactose-and AlCl3-inducedspatial memory impairment by restoring the dysfunction of the neurotransmitter systems in the rat model of Alzheimer's disease. Journal of Ethnopharmacology, 2016, 194(48): 188-195
(32)Yinghui Ma, MengyingWei, Yuanyuan Liu, Fengrui Song, Zhongying Liu, Zifeng Pi. Study on intestinal transport of Veratrum alkaloids compatible with Panax ginseng across the Caco-2 cell monolayer model by UPLC-ESI-MS method. Chinese Chemical Letters,2016, 26(2): 215-220
(33)苏玲，刘舒，刘志强，宋凤瑞*.人参-灵芝共发酵过程中产物的抗氧化活性及其成分变化规律研究[J].食品工业与发酵科技, 2016, 52(6):41-48
(34)Xiudong Yang, Xue Li, Ying Xu, Zifeng Pi, Na Lin, Zhiqiang Liu, Fengrui Song*. Mechanism of incompatible herb pairs, Panax ginseng and Veratrumnigrum L.: material basis and metabolic profiles of ginsenosides in rat intestinal bacteria. Chinese Journal of Chemistry, 2015, 33 (9), 1069-1076
(35)侯广月, 郑重, 宋凤瑞*, 刘志强, 赵冰. 基于紫外及荧光光谱方法的中药抗氧化应激作用研究. 光谱学与光谱分析, 2015, 03,680-683.(SCI)
(36)Guangyue Hou , Lu Wang, Shu Liu , Fengrui Song*, Zhiqiang Liu. Inhibitory effect of eleven herbal extracts on advanced glycation end-products formation and aldose reductase activity. Chinese Chemistry Letters,2014, 25(7): 1039-1043
(37)倩倩，张静，皮子凤，刘舒，宋凤瑞，刘志强*. 在线微透析-液相色谱-串联质谱法测定人参水提物对糖尿病脑病大鼠脑内神经活性物质的影响[J]. 分析化学, 2014, 07, 997-1001
(38)Xiaoyu Zhuang, Shu Liu, Ruixing Zhang, Fengrui Song*, Zhiqiang Liu*, Shuying Liu. Identification of Unfolding and Dissociation Pathways of Superoxide Dismutase in the Gas Phase by Ion-Mobility Separation and Tandem Mass Spectrometry. Analytical Chemistry. 2014, 86: 11599-11605.
(39)Guang-Yue Hou, Lu Wang, Shu Liu, Feng-Rui Song*, Zhi-Qiang Liu. Inhibitory effect of eleven herbal extracts on advanced glycation end-products formation and aldose reductase activity. Chinese Chem. Lett., 2014, 25(7): 1039-1043
(40)于晓礼,皮子凤,胡秀丽,宋凤瑞,刘志强. 高速逆流色谱结合电喷雾多级串联质谱方法高效分离制备、鉴定五味子木脂素类成分[J]. 药学学报,2014,01:78-82.
(41)毕云枫,宋凤瑞,刘志强. 天然酪氨酸酶抑制剂的种类及其对酪氨酸酶抑制作用的研究进展[J]. 吉林大学学报(医学版),2014,02:454-459.
(42)Hongbin Zhu, Chunyan Wang, Yao Qi, Fengrui Song*, Zhiqiang Liu, Shuying Liu. Fingerprint analysis of Radix Aconiti using ultra-performance liquid chromatography- electrospray ionization/ tandem mass spectrometry (UPLC-ESI/MSn) combined with stoichiometry. Talanta, 2013, 103, 56-65.
(43)Hongbin Zhu; Shu Liu; Xue Li, Fengrui Song*, Zhiqiang Liu,SHuying Liu.. Bioactivity fingerprint analysis of cyclooxygenase-2 ligands from radix Aconiti by ultrafiltration- UPLC-MSn, Anal. Bioanal. Chem., 2013,405(23):7437-7445
(44)Guangyue Hou, Jun Niu, Fengrui Song*, Zhiqiang Liu, Shuying Liu. Studies on the interactions between ginsenosides and liposome by equilibrium dialysis combined with ultrahigh performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography B ,2013,923:1-7
(45)Debin Wan,, Hongmei Yang, Fengrui Song, Zhiqiang Liu, Shuying Liu. Identification of isomeric disaccharides in mixture by the 1-phenyl-3-methyl-5-pyrazolone labeling technique in conjunction with electrospray ionization tandem mass spectrometry. Analytica Chimica Acta, 2013, 780: 36-45.
(46)Chen Xu, Shu Liu, Zhiqiang Liu, Fengrui Song, Shuying Liu. Superoxide Generated by pyrogallol reduces highly water-soluble tetrazolium salt to produce a soluble formazan: a simple assay for measuring superoxide anion radical scavenging activities of biological and abiological samples. Analytica Chimica Acta, 2013, 793(1): 53-60.
(47)Chunyan Wang, Wenyan Zhang, Fengrui Song*, Zhiqiang Liu, Shuying Liu. A simple method for the analysis by MS/MS of underivatized amino acids on dry blood spots from newborn screening. Amino Acids, 2012, 42,1889–1895
(48)Yuchi Zhang, Zifeng Pi, Chunming Liu, Fengrui Song, Zhiqiang Liu, Shuying Liu. Analysis of Low-polar Ginsenosides in Steamed Panax Ginseng at High-temperature by HPLC-ESI-MS/MS.Chemical Research in Chinese Universities, 2012, 28(1), 31-36
(49)Qinqin Du, Shuying Liu, Ruifeng Xu, Ming Li, Fengrui Song, Zhiqiang Liu. Studies on structures and activities of initial Maillard reaction products by electrospray ionisation mass spectrometry combined with liquid chromatography in processing of red ginseng. Food Chemistry, 2012, 135(2), 832-838
(50)郑重，宋凤瑞，刘志强，刘淑莹. 人参、红参皂苷类成分指纹图谱研究[J].质谱学报,2012, 33(6), 327-333
(51)杜芹芹，宋凤瑞，刘志强，刘淑莹. 红参加工过程中梅拉德初级反应产物的研究[J]. 化学学报, 2010, 68(13):1331-1336
(52)杜芹芹，张旭，宋凤瑞，刘志强，刘淑莹.人参与附子、黄连配伍的HPLC-ESI-MS 研究及抗氧化活性测定[J].高等学校化学学报，2010, 31(6): 1332-1336
(53)宋凤瑞，闫存玉，刘宁，刘志强，刘淑莹. 利用电喷雾质谱研究单链寡聚核苷酸与人参皂苷的相互作用. 化学学报, 2009,67(10): 103-1108
(54)Xu Zhang, Fengrui Song, Zhiqiang Liu, Shuying Liu. Investigation of the hydrolysis of ginsenosides by high performance liquid chromatography –electrospray ionization mass spectrometry. Planta Medica, 2007,73:1225 -1229
(55)张旭，宋凤瑞，刘志强，刘淑莹. pH值对人参皂苷溶出影响规律的液质联用研究[J].高等学校化学学报, 2006, 27: 1640-1644(SCI)
(56)Fengrui Song, Zhiqiang Liu, Shuying Liu, Zongwei Cai. Differentiation and identification of ginsenoside isomers by electrospray ionization tandem mass spectrometry. Analytica Chimica Acta, 2005,531 (1): 69-77
(57)Li Li, Rong Tsao, Jianpeng Dou, Fengrui Song, Zhiqiang Liu, ShuyingLiu. Detection of saponins in extract of Panaxnotoginseng by liquid chromatography-electrospray ionization-mass spectrometry. Analytica Chimica Acta, 2005, 536, 21-28.
(58)Meng Cui，Fengrui Song，Zhiqiang Liu，Shuying Liu. Metal ion adducts in the structural analysis of ginsenosides by electrospary ionization with multi-stage mass spectrometry. Rapid Communication in Mass Spectrometry. 2001,15: 586-595
(59)Lin JQ, Yu J, Sun L, Fang SG. Genome-Wide DNA Methylation and Transcriptome Analyses Reveal Epigenetic and Genetic Mechanisms Underlying Sex Maintenance of Adult Chinese Alligator. Front Genet. 2021;12:655900.
(60)Hu MY, Yu J, Lin JQ, Fang SG. Sex-Biased miRNAs in the Gonads of Adult Chinese Alligator (Alligator sinensis) and Their Potential Roles in Sex Maintenance. Front Genet. 2022;13:843884.